![]() 10, 11 However, it is unclear whether the centrality of negative symptoms and general functioning is conserved in comorbidity networks comprising broader symptom constellations. 6, 7 Thus, amelioration of negative symptoms-a longstanding pharmacotherapy challenge 8, 9-could potentially protect against global symptom cascades and improve overall illness states. ![]() ![]() Preliminary network studies identify negative symptoms and functioning levels as central to overall clinical profiles in schizophrenia. Network analysis has been used to identify the relative importance of symptoms in schizophrenia (ie, their degree of connectedness with other symptoms). 4, 5 This model suggests that psychiatric disorders reflect a causal interplay between multiple symptoms, whereby symptoms form meaningful associations and interactions with each other. 3 In this way, a collection of symptoms are represented as nodes (network elements) and their local interactions as edges. 1, 2 Recent studies have leveraged graph theory to reconceptualize symptoms as an interactive comorbidity network, rather than representing independent entities. However, it is increasingly clear that symptoms carry differing degrees of importance in terms of their impact on overall illness and may derive from numerous antecedents. No curative treatment exists, and first-line antipsychotic treatments do not relieve the full scope of symptoms and functional sequalae.ĭiagnostic classification of schizophrenia currently relies on categorical typologies, whereby symptoms are equally weighted and considered manifestations of an underlying illness. Schizophrenia is a complex mental health disorder, whose course is marked by gradual deterioration in psychopathology and brain structure.
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